What's your most wanted game? It can either be out already or it can be an upcoming game (or a theoretical one).
For me, I'm waiting for the next 2D Metroid, so much you wouldn't believe it. I swear, if Nintendo keeps up a trend of 3D on the DS and the Wii, I'll cry.
Seriously. 2D is so much better than 3D, especially when you're talking about Metroid.